Polyamines are non-specific marker of cellular proliferation in many malignant tumors, and it is also increase in certain benign conditions. We measured the urinary polyamines to investigate the possibility as a marker of abnormal prostate growth
and
the correlation with various clinical parameters. Urinary polyamine concentrations in 27 cases of symptomatic benign prostatic hyperplasia (BPH) wer ecompared with those in 32 cases of age matched normal controls. Urinary concentration of
polyamine
profiles were quantitatively determined by Gas Chromatography/Nitrogen Phosphorus Detector and they were caslculated by the corretion of gram creatinine. The concentrations of N-acetyl putrescine, N-acetyl cadaverine, spermidine(spd), N1-acetyl
spermidine, N8-acetly spermidine, and spermine(spm) showed significant increase in BPH compared with normal control)(all p<0.05). Level of serum prostate specific antigend(PSA) in BPH patients was negatively correlated with the concentration of
urinary
spermidine(p=0.049). And the ratio of spm/spd correlated with the level of prostate volume(p=0.046). No significant correlations was found betweend other clinical parameters such as age, level of hemoglobin or erythrocyte cound with polyamine
profiles
concentration.
These data suggested that urinary concentration of polyamines in BPH are elevated compared with those in normal control. Altered regulation of the biosynthesis and metabolism of spermidine and spermine may be involved in BPH.
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